Description
Psoralidin is a furanocoumarin isolated from the seeds of
P. corylifolia, a medicinal plant found in southeastern Asia, that has been shown to induce cytotoxicity against various cancer cells.
1 Through TNF-
related apoptosis-
inducing ligand-
mediated events, psoralidin at 50 μM can induce the death of HeLa cancer cells.
2 It also can induce apoptosis of androgen-
dependent (LNCaP, C4-
2B) and androgen-
independent (DU-
145, PC-
3) prostate cancer cells and inhibit the growth of PC-
3 xenograft tumors in nude mice.
3
References
[1] yang h j, youn h s, seong k m, et al. psoralidin, a dual inhibitor of cox-2 and 5-lox, regulates ionizing radiation (ir)-induced pulmonary inflammation[j]. biochemical pharmacology, 2011, 82(5): 524-534.
[2] chiou w f, don m j, liao j f, et al. psoralidin inhibits lps-induced inos expression via repressing syk-mediated activation of pi3k-ikk-iκb signaling pathways[j]. european journal of pharmacology, 2011, 650(1): 102-109.
[3] bronikowska j, szliszka e, jaworska d, et al. the coumarin psoralidin enhances anticancer effect of tumor necrosis factor-related apoptosis-inducing ligand (trail)[j]. molecules, 2012, 17(6): 6449-6464.
