1831135-30-8

JJH260 is an N-hydroxy hydantoin carbamate that inhibits androgen-induced gene 1 (AIG1), an enzyme that hydrolyzes fatty acid esters of hydroxy fatty acids (FAHFAs). It blocks the hydrolysis of 9-PAHSA with an IC₅₀ value of 0.57 μM.¹ JJH260 also inhibits the novel FAHFA hydrolase androgen-dependent TFPI-regulating protein (ADTRP; IC₅₀ = 8.5 μM), as well as the serine hydrolase ABHD6 and the lysophospholipases LYPLA₁ and LYPLA₂.¹ JJH260 inhibits the FAHFA hydrolase activity of LNCaP and T cell lysates and intact cells.¹

JJH260 is AIG1inhibitor, and inhibit the fluorophosphonate reactivity and fatty acid esters of hydroxy fatty acid (FAHFA) hydrolysis activity of AIG1in HEK293T cells, with IC50 values of 0.50 μM and 0.57 μM, respectively[1].

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1. Parsons, W.H., Kolar, M.J., Kamat, S.S., et al. AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Nat. Chem. Biol. 12(5),367-372(2016).