182417-73-8

Name	DPI-3290
CAS	182417-73-8
Molecular Formula	C30H34FN3O2
MDL Number	MFCD00937216
Molecular Weight	487.61
MOL File	182417-73-8.mol

Synonyms

DPI-3290 Org 41793 Benzamide, 3-[(R)-[(2S,5R)-2,5-dimethyl-4-(2-propen-1-yl)-1-piperazinyl](3-hydroxyphenyl)methyl]-N-(3-fluorophenyl)-N-methyl-

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Chemical Properties

Melting point	144-145 °C
Boiling point	620.4±55.0 °C(Predicted)
density	1.161±0.06 g/cm3(Predicted)
pka	9.80±0.10(Predicted)

Hazard Information

Uses

DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively. DPI-3290 is one of a series of novel centrally acting agents with potent antinociceptive activity[1].

in vivo

DPI-3290 (Org 41793) (intravenous; 0.05 mg/kg) produces a 50% antinociceptive response in rats^[1].

IC 50

κ Opioid Receptor/KOR; δ Opioid Receptor/DOR

References

[1] Gengo PJ, et al. DPI-3290 [(+)-3-((alpha-R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A mixed opioid agonist with potent antinociceptive activity. J Pharmacol Exp Ther. 2003 Dec;307(3):1221-6. DOI:10.1124/jpet.103.054361

Supplier

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