ChemicalBook CAS DataBase List 174641-44-2

174641-44-2

Name	L-Glutamic acid, L-threonyl-L-α-glutamyl-L-lysyl-L-lysyl-L-arginyl-L-arginyl-L-α-glutamyl-L-threonyl-L-valyl-L-α-glutamyl-L-arginyl-L-α-glutamyl-L-lysyl-
CAS	174641-44-2
Molecular Formula	C74H132N26O27
Molecular Weight	1818
MOL File	174641-44-2.mol

Chemical Properties

density	1.54±0.1 g/cm3(Predicted)
form	Solid
color	White to off-white

Hazard Information

Uses

HEP-1 (Human ezrin peptide (324 - 337)) is an orally active peptide with antiviral, anti-inflammatory, and immunomodulatory activities. HEP-1 is effective against infections by various viruses such as HIV, HCV, herpes viruses, HPV, and influenza viruses. As an immunomodulator, HEP-1 can enhance the adaptive immunity mediated by B cells and T cells. HEP-1 can also increase the antibody titers after hepatitis B vaccination. HEP-1 can be used in the research of viral infections and inflammation-related diseases[1][2].

in vivo

HEP-1 (2.25 mg/kg; intraperitoneal injection; once every two days; from day 1 to day 19) has a protective effect in the DSS (HY-116282C)-induced murine ulcerative colitis model^[1].

Animal Model:	Eight to ten weeks old male C57BL/6 mice (21-23 g) treated DSS (HY-116282C)^[1]
Dosage:	2.25 mg/kg
Administration:	Intraperitoneal injection (i.p.); once every two days; from day 1 to day 19
Result:	Significantly reduced the body weight loss, DAI score, and mortality rate of the mice. Inhibited the elevated expression of pro-inflammatory cytokines (such as IL-1β, IL-6, and Nos2) in colon tissues. significantly reduced the accumulation of Ly6G⁺ granulocytes and Ly6C⁺ monocytes in the colon infiltrate. Prevented the shortening of the colon caused by DSS colitis.

References

[1] Chulkina MM, et al. Pharmaceutical grade synthetic peptide Thr-Glu-Lys-Lys-Arg-Arg-Glu-Thr-Val-Glu-Arg-Glu-Lys-Glu ameliorates DSS-induced murine colitis by reducing the number and pro-inflammatory activity of colon tissue-infiltrating Ly6G+ granulocytes and Ly6C+ monocytes. Peptides. 2020 Oct;132:170364. DOI:10.1016/j.peptides.2020.170364
[2] Holms RD, et al. Ezrin Peptide Therapy from HIV to COVID: Inhibition of Inflammation and Amplification of Adaptive Anti-Viral Immunity. Int J Mol Sci. 2021 Oct 28;22(21):11688. DOI:10.3390/ijms222111688

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