Synthesis
Step 1: Synthesis of tert-butyl (3-hydroxybutyl)carbamate
To a stirred solution of (R)-4-aminobutan-2-ol (1.0 g, 11.2 mmol) in dichloromethane (20 mL) was slowly added a solution of di-tert-butyl dicarbonate (2.45 g, 11.2 mmol) in dichloromethane (20 mL). The reaction mixture was stirred at room temperature for 18 hours. After completion of the reaction, the organic phase was washed sequentially with aqueous citric acid and saturated aqueous sodium bicarbonate, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford the title compound tert-butyl (3-hydroxybutyl)carbamate as a colorless oil (2.1 g, 99% yield).
References
[1] Patent: WO2011/71725, 2011, A1. Location in patent: Page/Page column 55
[2] Patent: WO2011/71716, 2011, A1. Location in patent: Page/Page column 55
[3] Russian Journal of Bioorganic Chemistry, 2011, vol. 37, # 2, p. 225 - 230
[4] Patent: US5610195, 1997, A
