ChemicalBook CAS DataBase List 1646682-14-5

1646682-14-5

Name	FD-IN-1
CAS	1646682-14-5
Molecular Formula	C23H23NO4
MDL Number	MFCD32067952
Molecular Weight	377.43
MOL File	1646682-14-5.mol

Chemical Properties

Boiling point	629.4±55.0 °C(Predicted)
density	1.251±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	Solid
pka	4.14±0.10(Predicted)
color	White to off-white

Hazard Information

Biological Activity

FD-IN-1 (Compound 12) is a potent, orally active complement factor D (FD) inhibitor with IC50 of 12 nM.It also inhibits factor XIa (FXIa) and tryptase β2 with IC50 of 7.7 and 6.5 μM, respectively.

in vitro

FD-IN-1 (Compound 12) exhibits functional inhibition of AP activation (IC ₅₀ =0.26 μM) in vitro in a membrane attack complex (MAC) deposition assay using 50% human whole blood (WB).

in vivo

FD-IN-1 (Compound 12) demonstrates systemic suppression of AP activation in a lipopolysaccharide-induced alternative complement pathway (AP) activation model as well as local ocular suppression in intravitreal injection-induced AP activation model in mice expressing human FD.
FD-IN-1 (Compound 12) exhibits high oral bioavailability (C57BL6 mice 83%, Beagle dogs 70%) following oral administration (mice and dogs 10 mg/kg).
FD -IN-1 (Compound 12) exhibits terminal elimination half-lives (C57BL6 mice 1.6 h and Beagle dogs 3.8 h) following intravenous administration (mice and dogs 1 mg/kg).

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Animal Model: Human FD knock-in mice

Dosage: 3 and 10 mg/kg

Administration: Oral gavage

Result: The AP pathway was fully inhibited for up to 10 h at the 10 mg/kg dose.

Animal Model:	Human FD knock-in mice
Dosage:	3 and 10 mg/kg
Administration:	Oral gavage
Result:	The AP pathway was fully inhibited for up to 10 h at the 10 mg/kg dose.