1641574-26-6

Name	(Rac)-AMG8380
CAS	1641574-26-6
Molecular Formula	C25H16ClF2N3O5S
Molecular Weight	543.93
MOL File	1641574-26-6.mol

Synonyms

(Rac)-AMG8379 (Rac)-AMG8380 6-Quinolinesulfonamide, 1-(3'-chloro-2,5'-difluoro-5-methoxy[1,1'-biphenyl]-4-yl)-1,2-dihydro-N-3-isoxazolyl-2-oxo-

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Chemical Properties

Boiling point	752.0±70.0 °C(Predicted)
density	1.527±0.06 g/cm3(Predicted)
pka	4.89±0.20(Predicted)

Hazard Information

Uses

(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC50s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively [1].

IC 50

hNa_v1.7: 8.5 nM (IC₅₀); mNa_v1.7: 18.6 nM (IC₅₀)

References

[1] Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160. DOI:10.1124/jpet.116.239590

Spectrum Detail

(Rac)-AMG8380(1641574-26-6)¹HNMR

Supplier

Suzhou Zhixin Biotechnology Co., Ltd.

Telephone0512-65118909 18100677375

Websitehttp://www.szzxbio.com/

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

Sangon Biotech (Shanghai) Co.,Ltd.

Telephone400-821-026

Websitehttp://www.sangon.com

Guangzhou Taozhu Biotechnology Co., Ltd

Telephone4008200310

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1889346/0_EN.htm

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