Fluoroethylnormemantine (0.1-10 mg/kg; a single i.p.) shows anti-amnesic effects on Aβ?25-35-induced learning impairments in mice[1].
Fluoroethylnormemantine (0.1-10 mg/kg; i.p. once daily for 7 days) attenuates Aβ?25-35-induced behavioral deficits, neuroinflammation, oxidative stress, apoptosis, and cell loss in mice[1].
Fluoroethylnormemantine (1-20 mg/kg; a single injection) decreases behavioral despair in the forced swim test (FST) and reduces fear behavior in the cued fear conditioning (FC) and extinction training in rats[2].
| Animal Model: | Male Swiss CD-1 mice (7-9 weeks) were injected with Aβ25-35[1] |
| Dosage: | 0.1, 0.3, 1, 3, 10 mg/kg |
| Administration: | I.p. 30 minutes before the behavioral tests |
| Result: | Attenuated Aβ?25-35-induced spontaneous alternation deficit, passive avoidance deficit, and novel object exploration deficit. |
