1628784-53-1

BG48 is a novel probe of chemo-optical modulation of epigenetically regulated transcription (COMET). It enables high-resolution, optical control of epigenetic mechanisms and photochromically inhibits human histone deacetylases using visible light.

BG48 is a potent HDAC inhibitor. BG48 inhibits the enzymatic activity of HDAC1 and HDAC2[1].

HDAC1; HDAC2

[1] Reis SA, et al. Light-controlled modulation of gene expression by chemical optoepigenetic probes. Nat Chem Biol. 2016 May;12(5):317-23. DOI:10.1038/nchembio.2042