1628214-07-2

Name	CPI 4203
CAS	1628214-07-2
Molecular Formula	C16H14N4O
Molecular Weight	278.31
MOL File	1628214-07-2.mol

Synonyms

CPI 4203

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Chemical Properties

Boiling point	499.4±55.0 °C(Predicted)
density	1.28±0.1 g/cm3(Predicted)
form	Solid
pka	-5.02±0.60(Predicted)
color	White to off-white

Hazard Information

Description

CPI-4203 is a selective inhibitor of KDM5 demethylases, structurally related to CPI 455. The KDM5 family of histone demethylases catalyzes the demethylation of histone H3 on lysine 4 (H3K4) and is required for the survival of drug-tolerant persister cancer cells (DTPs).

Uses

CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].

References

[1] Vinogradova M, et al. An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Nat Chem Biol. 2016 Jul;12(7):531-8. DOI:10.1038/nchembio.2085

Supplier

Shanghai EFE Biological Technology Co., Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Jinan Jiuli Biotechnology Co. , Ltd.

Telephone 15865264761

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList89365/0.htm

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

Nantong QuanYi Biotechnology Co., Ltd

Telephone0513-66337626 18051384581

Websitehttps://www.chemhifuture.com/

Hefei Mokai Pharmaceutical Technology Co., Ltd

Telephone 19355912709

Websitehttp://www.yxjchem.com/

Adooq Bioscience LLC

Telephone400-025-6535

Websitehttp://www.adooq.cn

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