The reaction was carried out with 2,4-dichlorothieno[3,2-d]pyrimidine (64) (8.68 g, 42.34 mmol) and morpholine (8.1 mL, 2.2 eq.) in methanol (150 mL) with stirring for 1 hour at room temperature. After completion of the reaction, the reaction mixture was filtered and washed sequentially with water and methanol to afford the target compound 2-chloro-4-(4-morpholinyl)thieno[3,2-D]pyrimidine (65) as a white solid (11.04 g, 100% yield). The product was characterized by 1H NMR (400 MHz, DMSO-d6): δ 3.74 (4H, t, J = 4.9 Hz), 3.90 (4H, t, J = 4.9 Hz), 7.40 (1H, d, J = 5.6 Hz), 8.30 (1H, d, J = 5.6 Hz).
![2,4-Dichlorothieno[3,2-d]pyrimidine](/CAS/GIF/16234-14-3.gif)
![2-Chloro-4-(morpholin-4-yl)thieno[3,2-d]pyrimidine](/CAS/GIF/16234-15-4.gif)