1610882-30-8

Orexin receptors R1 (OX1R) and OX2R mediate the action of the neuropeptides orexin A and orexin B. TCX-OX2-29 is an antagonist of OX2R (pK_i = 7.5) that exhibits >250-fold selectivity for hOX2R compared with hOX1R (IC₅₀s = 40 nM and >10,000 nM, respectively). It blocks the inhibitory action of orexin A on forskolin-induced cAMP formation.

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