General Description
ISOSORBIDE-5-MONONITRATE(16051-77-7) is a crystalline solid. ISOSORBIDE-5-MONONITRATE(16051-77-7) is very flammable and may be toxic by ingestion.
Reactivity Profile
The dinitrate, a heart drug, can detonate when dry, but is non explosive with 30% of water [J. Haz.. Mater., 1992, 32(1), 87]. The mononitrate would be expected to be less reactive.
Air & Water Reactions
Highly flammable.
Health Hazard
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Chemical Properties
white to light yellow crystal powde
Uses
A metabolite of Isosorbide Dinitrate. Used as an antianginal
Uses
antidepressant, 5HT reuptake inhibitor
Definition
ChEBI: Isosorbide mononitrate is a nitrate ester and a glucitol derivative. It has a role as a nitric oxide donor and a vasodilator agent.
Brand name
Imdur (Schering-Plough); Ismo (Dr. Reddy’s);
Monoket (Schwarz Pharma)
.
Clinical Use
Vasodilator:
Treatment and prophylaxis of angina
Adjunct in congestive heart failure
Drug interactions
Potentially hazardous interactions with other drugs
Avanafil: hypotensive effect significantly enhanced -
avoid.
Levosimendan: possible severe hypotension.
Riociguat: avoid concomitant use due to risk of
hypotension.
Sildenafil: hypotensive effect significantly enhanced
- avoid.
Tadalafil: hypotensive effect significantly enhanced
- avoid.
Vardenafil: hypotensive effect significantly enhanced
- avoid.
Metabolism
Unlike isosorbide dinitrate, isosorbide mononitrate does
not undergo first-pass hepatic metabolism. Isosorbide
mononitrate is taken up by smooth muscle cells of blood
vessels and the nitrate group is cleaved to inorganic
nitrite and then to nitric oxide. Isosorbide mononitrate is
metabolised to inactive metabolites, including isosorbide
and isosorbide glucuronide
