159432-28-7

A 779 is an angiotensin heptapeptide analog antagonist.

A-779 (D-Ala7-Ang-(1-7)) is a potent and selective antagonist of angiotensin (1-7), an endogenous peptide that acts through activation of a non-AT1, non-AT2 receptor, Mas, and opposes the activity of angiotensin. A-779 has an IC50 of 0.3 nM for Mas with negligible affinity for either AT1R or AT2R.

This peptidomimetic Mas antagonist (FW = 872.98 g/mol; CAS 159432- 28-7; Sequence: Asp-Arg-Val-Tyr-Ile-His-D-Ala (or DRVYIH-D-A); Solubility: 1 mg/mL H2O) targets the Mas receptor, or Ang- (1-7) Receptor, the Class I seven-transmembrane G-protein-coupled angiotensin- (1-7) receptor that preferentially couples to the Gq protein, thereby activating the phospholipase C signaling pathway, with roles in hypotension, smooth muscle relaxation and cardio-protection by mediating the effects of angiotensin- (1-7). A-779 exhibits no significant affinity for AT1 or AT2 receptors at a concentration of 1 μM. It also inhibits antidiuretic effect of Ang- (1-7) in water-loaded rats. A779 attenuates monocrotaline-induced pulmonary fibrosis in rats.

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