1557232-32-2

GNE-9822 is a potent and selective ITK inhibitor. GNE-9822 shows good ADME properties in preclinical species. Interleukin-2 inducible T-cell kinase (ITK), a member of the Tec family of tyrosine kinases, plays a major role in T-cell signaling downstream of the T-cell receptor (TCR), and considerable efforts have been directed toward discovery of ITK-selective inhibitors as potential treatments of inflammatory disorders such as asthma.