15548-51-3

5'-TMPS (Thymidine-5'-O-monophosphorothioate) is a selective partial agonist of P2Y6R and an antagonist of P2Y14R. Additionally, 5'-TMPS acts as a positive regulator of angiogenesis, exhibiting pro-angiogenic effects[1][2]

[1] Rafehi M, et al. Tools and drugs for uracil nucleotide-activated P2Y receptors[J]. Pharmacology & Therapeutics, 2018, 190: 24-80. DOI:10.1016/j.pharmthera.2018.04.002
[2] W?g?owska E, et al. Extracellular nucleotides affect the proangiogenic behavior of fibroblasts, keratinocytes, and endothelial cells[J]. International Journal of Molecular Sciences, 2021, 23(1): 238. DOI:10.3390/ijms23010238