Zaragozic acid D is a squalene synthase inhibitor. Zaragozic acid D also is a farnesyl-protein transferase (FPTase) inhibitor with an IC50 value of 100 nM for bovine FPTase[1][2].
References
[1] Leeyuan Huang, et al. New fungal metabolites as potential antihypercholesterolemics and anticancer agents. Canadian Journal of Botany, 1995, 73(S1): 898-906. [2] Dufresne C, et al. Zaragozic acids D and D2: potent inhibitors of squalene synthase and of Ras farnesyl-protein transferase. J Nat Prod. 1993 Nov;56(11):1923-9. DOI:10.1021/np50101a009
