MK-8153 (0.1-10 mg/kg/d, p.o. once daily for 3 days) causes a dose-dependent decrease in systolic blood pressure of aged SHRs. MK-8153 shows diuretic effects in SHRs[1].
MK-8153 (2 mg/kg; p.o.) exhibits terminal elimination half-lives (rat 3.6, dog 9.1, Rhesus 3.3 h), bioavailability (rat 53%, dog ~100%, Rhesus 3.4%), and plasma clearance (rat 29.4, dog 8.7, Rhesus 58.3 mL/min/kg)[1].
| Animal Model: | Aged spontaneously hypertensive rats (SHRs)[1] |
| Dosage: | 0.1, 0.3, 1, 3, 10 mg/kg |
| Administration: | P.o. once daily for 3 days |
| Result: | Observed the maximal lowering of systolic blood pressure (～24 mm Hg) by day 3 at the 3 mg/kg.
Dose-dependently increased the sodium excretion.
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