1528546-94-2

Name	BPI-9016M
CAS	1528546-94-2
Molecular Formula	C25H18F2N4O3
MDL Number	MFCD34469316
Molecular Weight	460.43
MOL File	1528546-94-2.mol

Synonyms

BPI-9016M

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Chemical Properties

Boiling point	667.4±55.0 °C(Predicted)
density	1.431±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
form	Solid
pka	8.80±0.69(Predicted)
color	Light yellow to brown

Hazard Information

Description

BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma.

Uses

BPI-9016M is a potent, orally active, and selective dual c-Met and AXL tyrosine kinases inhibitor. BPI-9016M suppresses tumor cell growth, migration and invasion of lung adenocarcinoma[1][2].

in vivo

BPI-9016M (60 mg/kg; p.o.; daily for 16 or 12 days) dramatically restrains tumor growth in PDX xenografts in NOD/SCID mice^[2].

Animal Model:	NOD/SCID mice^[2]
Dosage:	60 mg/kg
Administration:	p.o.; daily for 16 or 12 days
Result:	Dramatically restrained tumor growth in PDX xenografts in NOD/SCID mice.

References

[1] Zhang P, et al. BPI-9016M, a c-Met inhibitor, suppresses tumor cell growth, migration and invasion of lung adenocarcinoma via miR203-DKK1. Theranostics.?2018 Nov 12;8(21):5890-5902. DOI:10.7150/thno.27667
[2] Hu X, et al. First-in-human phase I study of?BPI-9016M, a dual MET/Axl inhibitor, in patients with non-small cell lung cancer.J Hematol Oncol.?2020 Jan 16;13(1):6. DOI:10.1186/s13045-019-0834-2

Supplier

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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