1483-01-8

L-Homoarginine is an uncompetitive and organ-specific inhibitor of alkaline phosphatases. This non-essential amino acid inhibits human bone and liver alkaline phosphatases but has no effect on placental or intestinal isoenzymes. In vitro, L-homoarginine inhibits [³H]thymidine uptake by mouse myeloma MOPC 104E cells and inhibits proliferation of C3H/He mouse osteosarcoma cells. Pre-treatment with L-homoarginine delays in vivo tumor growth in a murine C3H/He osteosarcoma model. It also inhibits high-protein diet-induced pancreatic growth and enzyme secretion in bile-pancreatic juice-diverted rats, a model for the induction of pancreatic enzyme secretion with hypercholecystokininemia.

White Powder

An inhibitor of alkaline phosphatase isoenzymes. An analog of Homoarginine (H585000).

An inhibitor of alkaline phosphatase isoenzymes. It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter. The substitution of homoarginine for arginine or lysine renders proteins resistant to proteolysis by trypsin. Arginine residues are often located at the active centers of proteins and enzymes. Replacing these arginines with homoarginine can elucidate protein function and structural requirements.

Homoarginine is an inhibitor of tissue nonspecific alkaline phosphatase (TNALP). It is also an inhibitor of cellular transport of arginine by a sodium-independent high affinity y+ transporter.

Human Endogenous Metabolite

[1] CHI-WEI LIN W F. L-Homoarginine. An organ-specific, uncompetitive inhibitor of human liver and bone alkaline phosphohydrolases.[J]. The Journal of Biological Chemistry, 1972, 16 1: 3082-3087. DOI: 10.1016/s0021-9258(19)45215-0
[2] Y KIKUCHI  K K  I Kizawa. [Inhibitory effect of L-homoarginine on murine osteosarcoma cell proliferation].[J]. Japanese Journal of Cancer and Chemotherapy, 1982, 9 5: 888-897.
[3] T. HIRA  H. H  S Ohyama. l-Homoarginine suppresses exocrine pancreas in rats[J]. Amino Acids, 2003, 24 4: 389-396. DOI: 10.1007/s00726-002-0344-2