1467059-70-6

PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research[1].

AMPK α1β1γ1: 12 nM (EC₅₀)

Store at -20°C

[1] David J Edmonds, et al. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK). J Med Chem. 2018 Mar 22;61(6):2372-2383. DOI:10.1021/acs.jmedchem.7b01641