Makaluvamine A comes from the fruiting bodies of Didymium bahiense that act as active anti-cancer agents and DNA topo II inhibitors.
Uses
Makaluvamine A is a member of Makaluvamines. Makaluvamines can be isolated from Fijian sponges of the genus Zyzzya, and possess inhibitory activity toward topoisomerase II along with cytotoxic activity against HCT-116 human colon cancer cells[1].
References
[1] An J, et al. Pyrroloiminoquinone Alkaloids: Total Synthesis of Makaluvamines A and K. Org Lett. 2023 Mar 24;25(11):1868-1871. DOI:10.1021/acs.orglett.3c00350
