BO 2367 is a topoisomerase inhibitor with applications to tumor growth suppression.
Uses
(-)-BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-)-BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-)-BO 2367 is a potent antitumor agent[1].
IC 50
Topoisomerase II
References
[1] T Yoshinari, et al. Stereo (C7)-dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367. Jpn J Cancer Res. 1993 Jul;84(7):800-6. DOI:10.1111/j.1349-7006.1993.tb02047.x
