1448808-50-1

5-HT7R antagonist 2 (compound 4h) is a 5-HT7R antagonist that antagonizes the G protein and β-arrestin signaling pathways, with a Ki of 67 nM, the IC50 values in cAMP and Tango tests were 2.59 μM and 39.57 μM, respectively. 5-HT7R antagonist 2 has an effect on neurogenesis and can reduce repetitive behaviors related to autism spectrum disorder (ASD) and restore neurogenesis of ASD impairment[1].

5-HT₇ Receptor: 67 nM (Ki)

[1] Jeong JH, et al. Identification of an Antagonist Targeting G Protein and β-Arrestin Signaling Pathways of 5-HT7R. ACS Chem Neurosci. 2024;15(5):1026-1041. DOI:10.1021/acschemneuro.3c00738