1443242-46-3

p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].

p38α: 0.1 nM (IC₅₀); p38β: 0.2 nM (IC₅₀); p38γ: 944 nM (IC₅₀); p38δ: 4100 nM (IC₅₀)

[1] Elisabetta Armani, et al. Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem. 2022 May 26;65(10):7170-7192. DOI:10.1021/acs.jmedchem.2c00115