Metallo-β-lactamase-IN-6 (100 mg/kg; IP; single) reaches plasma concentration peak about 9 min after injection with an effective maximum concentration of 142.8 μg/ml, and the T1/2 is 1.24 hours[1].
Metallo-β-lactamase-IN-6 (500, 1000, or 2000 mg/kg; IP; single, observe for 14 days) does not result in any significant toxic effects and is well-tolerated by mice at a dose of ≤ 2000 mg/kg[1].
Pharmacokinetic Parameters of Metallo-β-lactamase-IN-6 in male female ICR mice[1].
| IP (100 mg/kg) |
| T1/2 (h) | 1.243 |
| Cmax (μg/mL) | 142.8 |
| Tmax (h) | 0.151 |
| Vd (mL/kg) | 535.804 |
| CL (mL/h/kg) | 248.512 |
| AUC0-∞ (μg/mL·h) | 896 |
| Animal Model: | Female ICR mice (180-220 g)[1] |
| Dosage: | 100 mg/kg |
| Administration: | IP; single (Pharmacokinetics Analysis) |
| Result: | Plasma concentration reached its peak about 9 min after injection with an effective maximum concentration of 142.8 μg/ml, and the T1/2 was 1.24 hours. |
| Animal Model: | Female ICR mice (n=5)[1] |
| Dosage: | 500, 1000, or 2000 mg/kg |
| Administration: | IP; single, observed for 14 days |
| Result: | Did not result in any significant toxic effects and was well-tolerated by mice at a dose of ≤ 2000 mg/kg. |
