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1430741-35-7
1430741-35-7
Name
CFI-401870
CAS
1430741-35-7
Molecular Formula
C30H31N5O2
Molecular Weight
493.6
MOL File
1430741-35-7.mol
Synonyms
CFI401870
CFI-401870
1H-Indazole-5-carboxamide, N-[(R)-cyclopropyl-2-pyridinylmethyl]-3-[4-[(3-endo)-3-hydroxy-8-azabicyclo[3.2.1]oct-8-yl]phenyl]-
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Description
CFI-401870 is a orally bioavailable, potent tyrosine threonine kinase (TTK) Inhibitor (TTK IC50 < 10 nM, HCT116 GI50 < 0.1 μM). CFI-401870 displayed low off-target activity (>500×), and microsomal stability (T(1/2) > 30 min). CFI-401870 recapitulated the phenotype of TTK RNAi, demonstrated in vivo tumor growth inhibition upon oral dosing, and was selected for preclinical evaluation.
Supplier
ShangHai Biochempartner Co.,Ltd
Telephone
17754423994 17754423994
Website
https://www.biochempartner.com
Hangzhou Synstar pharmaceutical Technology CO.,Ltd
Telephone
0571-85361029
Website
https://www.chemicalbook.com/ShowSupplierProductsList31097/0.htm
Hubei Kele Fine Chemical Co., Ltd
Telephone
027-59101668 19945030958
Website
http://www.kerle.cn
https://hanhongsci.com/
Telephone
021-54306202 18917919676
Website
https://www.hanhongsci.com/
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