1423067-48-4

Name	BI 703704
CAS	1423067-48-4
Molecular Formula	C32H37N3O4S
MDL Number	MFCD32671339
Molecular Weight	559.72
MOL File	1423067-48-4.mol

Synonyms

BI 703704 (Rac)-BI 703704 (Rac)BI 703704,(Rac) BI 703704 3-Azabicyclo[3.2.1]octane-8-carboxylic acid, 3-[4-[5-methyl-2-[[2-methyl-4-(1-piperidinylcarbonyl)phenyl]methoxy]phenyl]-2-thiazolyl]-

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Chemical Properties

Boiling point	762.3±70.0 °C(Predicted)
density	1.269±0.06 g/cm3(Predicted)
form	Solid
pka	4.21±0.20(Predicted)
color	White to off-white

Hazard Information

Uses

(Rac)-BI 703704 is a potent soluble guanylyl cyclase (sGC) activator. (Rac)-BI 703704 reduces progression of renal damage in the ZSF1 rat, and highlight the potential of sGC activation as an effective therapy for diabetic nephropathy[1].

in vivo

(Rac)-BI 703704 (0.3-10 mg/kg; food intake; daily for 15 weeks) inhibits the progression of diabetic nephropathy in the ZSF1 rat^[1].

Animal Model:	12-13 weeks male ZSF1 obese rats^[1]
Dosage:	0.3, 1, 3, or 10 mg/kg
Administration:	Food intake; daily for 15 weeks
Result:	Dose-dependent increased in renal cGMP levels; Dosedependent decreased in urinary protein excretion (UPE); Accompanied by a significant reduction in the incidence of glomerulosclerosis and interstitial lesions.

References

[1] Yu L, et al. Picrocrocin exhibits growth inhibitory effects against SKMEL- 2 human malignant melanoma cells by targeting JAK/ STAT5 signaling pathway, cell cycle arrest and mitochondrial mediated apoptosis. J BUON. 2018 Jul-Aug;23(4):1163-1168. PMID:30358226

Supplier

RD International Technology Co., Limited

Telephone 18024082417

Websitehttps://www.ruidiresearch.com

TargetMol Chemicals Inc.

Telephone 15002134094

Websitehttps://www.targetmol.cn/

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