1421941-29-8

Neosartoricin is a prenylated tricyclic polyketide produced in A. fumigatus and N. fischeri overexpressing the N. fischeri polycyclic prenyltransferase (pcPTase) nsc gene cluster.1 It inhibits the proliferation of anti-CD3 and anti-CD28-stimulated mouse spleen T cells (IC50 = 2.99 μM).

1.Chooi, Y.-H., Fang, J., Liu, H., et al.Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungiOrg. Lett.15(4)780-783(2013)