| Toxicity |
A hallucinogenic (psychedelic) agent. It may catalyze
the onset of emotional problems or psychosis in predisposed
individuals. Although the mechanism of action for hallucinogens
is not understood, DOM is believed to act by being an
agonist at serotonin 5-HT2 receptors. It causes hyperreflexia,
restlessness, and perceptual alterations in illusions, including
changes in touch, taste, and odor, and the thinking process is
substantially altered. At high doses, hallucinations and loss of
contact with reality result. The duration of action may be
16-24 h. Its LD50 is in mice 36 mg/kg, i.v., in rats 32.5 mg/
kg, i.p., in dogs 7.2 mg/kg, i.v., and in monkeys 8 mg/kg, i.v.
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