1408077-04-2

ZG-10 is a JNK1 inhibitor, which targets JNK and p38 signaling.

ZG-10 (JNK-IN-2) is a JNK inhibitor, with IC50 values of 809 nM, 1140 nM and 709 nM for JNK1, JNK2, and JNK3, respectively. ZG-10 (JNK-IN-2) is a potential anti-SARS-CoV-2 agent[1][2].

ChEBI: 4-[[4-(dimethylamino)-1-oxobut-2-enyl]amino]-N-[3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide is a member of benzamides.

JNK1: 809 nM (IC₅₀); JNK2: 1140 nM (IC₅₀); JNK3: 709 nM (IC₅₀)

[1] Tinghu Zhang, et al. Discovery of potent and selective covalent inhibitors of JNK. Chem Biol. 2012 Jan 27;19(1):140-54. DOI:10.1016/j.chembiol.2011.11.010
[2] Rui Zhang, et al. Inflammatory activation and immune cell infiltration are main biological characteristics of SARS-CoV-2 infected myocardium. Bioengineered. 2022 Feb;13(2):2486-2497. DOI:10.1080/21655979.2021.2014621