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white powder

4-tert-Octylphenol (4t-OP) is used in manufacturing processes as an intermediate in the generation of surfactants, synthetic rubber additives, or resins. 4t-OP is also used to manufacture alkylphenol ethoxylates. It is found mainly in detergents, cleaning products, and emulsifiers and less frequently in paints, personal care products, pesticides, paper, pulp, and textiles. There is a paucity of data on food levels of 4t-OP, with one study reporting 19 ng g^-1 wet weight 4t-OP in baby food and similar concentrations reported in seafood. Urinary 4t-OP reflects recent exposure; the 95th percentile (confidence interval) urine concentration of 4t-OP in the US population as reported by the US Centers for Disease Control in the National Health and Nutrition Examination Survey is 2.2 (1.6–3.2) mg l^-1.

A common environmental pollutant showing weak estrogenic effects. 4-tert-Octylphenol has been shown to cause harm to the male reproductive system of vertebrates.

Surfactants, Tackifier Resins, Ink Resins, Polycarbonate Chain Terminator, Ultraviolet Stabilizers

ChEBI: 4-tert-Octylphenol is an alkylbenzene.

4-tert-octylphenol can affect the reproductive system of animals and affect how babies develop. It can also affect how hormones are produced in animals.
High doses of several alkylphenols, including 4- tert-octylphenol, have altered estrogenic effects, including sex hormone levels, estrus cycles, reproductive outcomes, neonatal sexual development, as well as impaired production of steroid hormone and testicular atrophy.

Studies have shown that 4t-OP will adsorb to sediments.

Crystallise the phenol from n-hexane and/or distil it in a vacuum. [Beilstein 6 III 2051, 6 IV 3484.]

4t-OP has been shown to be an estrogen receptor (ER) agonist. Estrogenic effects of 4t-OP have been demonstrated in human cells, with 4t-OP displacing the natural estrogen 17b estradiol from its receptor, and 4t-OP inducing cell proliferation in estrogen-dependent cell proliferation assays. In vivo confirmation of 4t-OP’s estrogenicity has been confirmed with the uterotrophic assay.