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To a 100 mL round bottom flask was added 2-bromo-8-acetoxyquinoline (1.8 g, 6.6 mmol), potassium hydroxide (1.1 g, 20 mmol) and 16 mL of ethanol. The reaction mixture was heated to 50°C with continuous stirring for 3 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. Water was added to the residue to obtain a clarified solution and the pH was adjusted to neutral with dilute hydrochloric acid. Subsequently, the aqueous phase was extracted with dichloromethane (CH2Cl2), the organic phases were combined and dried over anhydrous sodium sulfate (Na2SO4). The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give 1.5 g of the white solid product 2-bromoquinolin-8-ol in 99% yield.

[1] Patent: CN108947898, 2018, A. Location in patent: Paragraph 0058; 0063; 0064
[2] Journal of Organic Chemistry, 2010, vol. 75, # 2, p. 424 - 433
[3] Monatshefte fuer Chemie, 1991, vol. 122, # 11, p. 935 - 942