SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice[1].
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1].
| Animal Model: | Adult double-transgenic CK-p25 mice (3-month-old)[1] |
| Dosage: | 30 mg/kg |
| Administration: | Oral gavage, daily, for 6 weeks |
| Result: | Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals. |
