WS009B is a selective endothelin receptor antagonist (ET-1: IC50=0.67 μM; ET-2: IC50=0.8 μM). WS009B can be used in the study of cardiovascular diseases[1].
IC 50
ETA: 0.67 μM (IC50); ETB: 0.8 μM (IC50)
References
[1] MIYATA S, et al. WS009 A and B, new endothelin receptor antagonists isolated from Streptomyces sp. No. 89009 I. Taxonomy, fermentation, isolation, physico-chemical properties and biological activities[J]. The Journal of Antibiotics, 1992, 45(7): 1029-1040. DOI:10.7164/antibiotics.45.1029
