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DLC27-14 is a specific protein disorder catalyzer of HIV-1 Nef.

DLC27-14 is a HIV Nef inhibitor with the IC50 of 15.92 μM. DLC27-14 can be used for study of HIV-1[1][2].

[1] Lugari A, et al. A specific protein disorder catalyzer of HIV-1 Nef. Bioorg Med Chem. 2011;19(24):7401-7406. DOI:10.1016/j.bmc.2011.10.051
[2] Trible RP, et al. Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen. Retrovirology. 2013;10:135. Published 2013 Nov 14. DOI:10.1186/1742-4690-10-135