P516-0475 is a novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO. This compound induces quorum sensing by stabilizing SHP pheromones in culture.
Uses
P516-0475 is an uncompetitive inhibitor against endopeptidase PepO. P516-0475 is also an agonist of the Rgg2/3 system with antibacterial activity. P516-0475 induces expression of Rgg2/3-regulated genes in the presence of short hydrophobic pheromone (SHP) for activity and leads to positive modulation of lysozyme resistance[1][2].
References
[1] Morales T G P, et al. A novel chemical inducer of Streptococcus quorum sensing acts by inhibiting the pheromone-degrading endopeptidase PepO[J]. Journal of Biological Chemistry, 2018, 293(3): 931-940. DOI:10.1074/jbc.M117.810994 [2] Nepomuceno VM, et al. A Streptomyces tendae Specialized Metabolite Inhibits Quorum Sensing in Group A Streptococcus. Microbiol Spectr. 2023 Aug 17;11(4):e0527922. DOI:10.1128/spectrum.05279-22
