Befloxatone (0.75 mg/kg; i.p.; single dose) increases tissue levels of monoamines and decreases levels of their deaminating metabolites in rats[1].
Befloxatone (1 mg/kg; i.p.; single dose) induces elevated levels of dopamine and corticonorepinephrine in the extracellular striatum of rats, but not elevates levels of corticoserotonin[1].
Befloxatone (0.03-0.3 mg/kg; p.o.; single dose) effectively inhibits the firing rate of serotonergic neurons and partially reduces the firing of norepinephric neurons, but had no effect on the firing of dopaminergic neurons in rats[1].
Befloxatone (1.5 mg/kg; p.o.; single dose) does not enhance the pressor effect of the central active dose of oral tyramine and has a broad safety profile in rats[1].
