Clathrin-IN-1 is a elective clathrin inhibitor. It acts by addressing clathrin function in cell physiology with potential applications as inhibitor of virus and pathogen entry and as modulator of cell signaling.
Uses
Pitstop 1 is a small molecule inhibitor with endocytosis-inhibiting activity. Pitstop 1 blocks the interaction of chaperones with the Krasin terminal domain in cells, thereby affecting the function of Krasin. Pitstop 1 exhibits superior biological activity in significantly inhibiting the effects of Krasin. Pitstop 1 acts as a dose that inhibits the entry of viruses and pathogens into cells and modulates cell signaling[1].
References
[1] Development of 1,8-naphthalimides as clathrin inhibitors DOI:10.1021/jm4015263
