132-93-4

Name	PHENETHICILLIN POTASSIUM SALT
CAS	132-93-4
EINECS(EC#)	205-084-4
Molecular Formula	C17H19KN2O5S
MDL Number	MFCD00082379
Molecular Weight	402.51
MOL File	132-93-4.mol

Chemical Properties

color

dl-Form: Crystals from acetone

Safety Data

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P261-P285-P304+P341-P342+P311-P501
Hazardous Substances Data	132-93-4(Hazardous Substances Data)
Toxicity	LD50 oral in mouse: > 2gm/kg less more

Hazard Information

Originator

Syncillin, Bristol, US ,1959

Definition

ChEBI: Phenethicillin potassium is an organic potassium salt. It contains a phenethicillin(1-).

Manufacturing Process

Triethylamine (1.5 ml) was added to a cold solution (10°C) of αphenoxypropionic acid (1.66 g, 0.01 mol) in 15 ml of pure dioxane, with stirring and cooling to 5°C to 10°C while isobutyl chloroformate (1.36 g, 0.01 mol) in 5 ml of dioxane was added dropwise. Then the mixture was stirred for ten minutes at 5°C to 8°C. A solution of 6-amino-penicillanic acid (2.16 g, 0.01 mol) in 15 ml of water and 2 ml of triethylamine was then added dropwise while the temperature was maintained below 10°C. The resulting mixture was stirred in the cold for 15 minutes then at room temperature for 30 minutes, diluted with 30 ml of cold water and extracted with ether which was discarded. The cold aqueous solution was then covered with 75 ml of ether and acidified to pH 2 with 5 N H2SO4. After shaking, the ether layer containing the product 6-(α-phenoxypropionamido)penicillanic acid, was dried for ten minutes over anhydrous sodium sulfate and filtered. Addition of 6 ml of dry n-butanol containing 0.373 g/ml of potassium 2-ethylhexanoate precipitated the potassium salt of the product as a colorless oil which crystallized on stirring and scratching and was collected, dried in vacuo and found to weigh 2.75 g, to melt at 217°C to 219°C.

Brand name

Chemipen (Bristol-Myers Squibb); Syncillin (Bristol-Myers Squibb) [Name previously used: Phenethicillin.].

Therapeutic Function

Antibacterial

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of K2O, SOx, and NOx.

Supplier

3B Pharmachem (Wuhan) International Co.,Ltd.

Telephone821-50328103-801 18930552037

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList13285/0.htm

Beijing HuaMeiHuLiBiological Chemical

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Websitehttp://www.huabeibiochem.com/

Shandong Xiya Chemical Co., Ltd.

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Websitehttp://www.xiyashiji.com

Shandong Ono Chemical Co., Ltd.

Telephone0539-6362799 20）

Websitehttp://www.onochem.com

AFINE CHEMICALS LIMITED

Telephone+86-0571-85134551

Websitehttp://www.afinechem.com/index.html

Shaanxi Dideu Medichem Co. Ltd

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Websitewww.dideu.com

Shandong Tianming Biotechnology Development Co. Ltd

Telephone400-9019001

Websitehttp://www.oknk.com/

TCI (Shanghai) Chemical Trading Co., Ltd.

Telephone021-021-61109150

Websitehttps://www.tcisct.com

Shaanxi DIDU pharmaceutical and Chemical Co., Ltd

Telephone 15229059051

Websitehttp://www.dideu.cn

TargetMol Chemicals Inc.

Telephone 4008200310

Websitehttps://www.targetmol.cn/

Shanghai Beiwanta Biotechnology Co., Ltd.

Telephone021-67187366 19901745723

Websitehttp://www.bwtlab.com/

Telephone 4008-099-669

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList112975/0.htm

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