ChemicalBook CAS DataBase List 1313439-71-2

1313439-71-2

Name	1H-Pyrido[2,3-b][1,4]oxazin-2(3H)-one, 6-[4-(cis-1-amino-3-hydroxycyclobutyl)phenyl]-1-ethyl-7-phenyl-
CAS	1313439-71-2
Molecular Formula	C25H25N3O3
Molecular Weight	415.48
MOL File	1313439-71-2.mol

Chemical Properties

Boiling point	664.8±55.0 °C(Predicted)
density	1.278±0.06 g/cm3(Predicted)
form	Solid
pka	14.69±0.40(Predicted)
color	Off-white to light yellow

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Animal Model:	BALB/c mice (bearing A549 xenografts)^[1]
Dosage:	10, 30 and 100 mg/kg
Administration:	p.o.; single dosage
Result:	Increased total plasma concentrations dose-dependently that resulted in almost total abrogation of measurable pAKT^S473 in tumors at all timepoints over 24 h. Exhibited the tumour growth inhibition (TGI) of 23, 31 and 41% at 10, 30 and 100 mg/kg, respectively.

Animal Model:	BALB/c mice (bearing PIK3CA-mutant MCF-7 xenografts)^[1]
Dosage:	3 or 10 mg/kg
Administration:	p.o.; q.d. for 49 days
Result:	Showed significant tumour regressions of 57% and 50% at 3 and 10 mg/kg, respectively, when combined with Tamoxifen (HY-13757A) (5 mg/kg; q.d.).

1313439-71-2

Chemical Properties

Hazard Information

Uses

in vivo

IC 50

References

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