ChemicalBook CAS DataBase List 131-56-6

131-56-6

Name	2,4-Dihydroxybenzophenone
CAS	131-56-6
EINECS(EC#)	205-029-4
Molecular Formula	C13H10O3
MDL Number	MFCD00002277
Molecular Weight	214.22
MOL File	131-56-6.mol

Synonyms

2,4-DIHYDROXYBENZOPHENONE (2,4-DIHYDROXY-PHENYL)-PHENYL-METHANONE 4-BENZORESORCINOL 4-BENZOYLRESORCINOL BENZOPHENONE-1 BENZORESORCINOL DHB DIHYDROXYBENZOPHENONE(2,4-) SYNSORB (2,4-dihydroxyphenyl)phenyl-methanon (2,4-Dihydroxyphenyl)-phenylmethanon (2,4-dihydroxybenzophenon) 2,4-DHBP 2,4-Dihydroxtbenzophenone 2,4-Dihydroxybenzofenon 2,4-dihydroxy-benzophenon 2,4-dihydroxydiphenylketone Advastab 48 advastab48 Benzophenone, 2,4-dihydroxy- Dastib 263

Chemical Properties

Appearance	yellow crystalline powder
Melting point	144.5-147 °C(lit.)
Boiling point	194 °C (1 mmHg)
bulk density	750kg/m3
density	1,32 g/cm³
vapor pressure	0Pa at 25℃
refractive index	1.5090 (estimate)
Fp	125 °C
storage temp.	-20°C
solubility	Chloroform (Slightly, Heated), Ethanol (Slightly, Heated)
form	Crystalline Powder
pka	7.72±0.35(Predicted)
color	Yellow
PH	5 (10g/l, H2O, 20℃)(slurry)
biological source	human
Water Solubility	insoluble
Merck	14,1106
BRN	1311566
Cosmetics Ingredients Functions	LIGHT STABILIZER UV ABSORBER
InChI	1S/C13H10O3/c14-10-6-7-11(12(15)8-10)13(16)9-4-2-1-3-5-9/h1-8,14-15H
Contact allergens	BZP-1 is used, for example, in paints, plastics, and nail varnishes. less more
InChIKey	ZXDDPOHVAMWLBH-UHFFFAOYSA-N
SMILES	Oc1ccc(c(O)c1)C(=O)c2ccccc2
LogP	2.964 at 25℃
CAS DataBase Reference	131-56-6(CAS DataBase Reference)
NIST Chemistry Reference	Methanone, (2,4-dihydroxyphenyl)phenyl-(131-56-6)
EPA Substance Registry System	Methanone, (2,4-dihydroxyphenyl)phenyl- (131-56-6)

Safety Data

Hazard Codes	Xi
Risk Statements	R36:Irritating to the eyes. R36/37/38:Irritating to eyes, respiratory system and skin . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S37/39:Wear suitable gloves and eye/face protection . less more
WGK Germany	2
RTECS	DJ0700000
Hazard Note	Irritant
TSCA	Yes
HS Code	29145000
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Chronic 2 Eye Irrit. 2 Repr. 2
Safety Profile	Poison by intravenous and intraperitoneal routes. Mildly toxic by ingestion. An eye irritant. When heated to decomposition it emits acrid smoke and irritating fumes. less more
Hazardous Substances Data	131-56-6(Hazardous Substances Data)
Toxicity	LD50 orally in Rabbit: > 5000 mg/kg less more

Raw materials And Preparation Products

Hazard Information

Chemical Properties

yellow crystalline powder

Uses

2,4-Dihydroxybenzophenone is an metabolite of Benzophenone (B204980), an compound used in the manufacturing of antihistamines, hypnotics and insecticides.

Uses

Ultraviolet light absorber, especially in paints and plastics.

Description

2,4-Dihydroxybenzophenone (DHP) is an organic compound derived from Garcinia xanthochymus, but there have been no reports on its biochemical functions and bioavailability. 2,4-dihydroxybenzophenone has been prepared by reacting resorcinol with benzoyl chloride or benzoic acid under anhydrous conditions in the presence of Friedel-Crafts catalysts such as AlCl3 or ZnCl2[1].

Definition

ChEBI: 2,4-Dihydroxybenzophenone is a member of benzophenones.

Preparation

Obtained by condensation of benzanilide with resorcinol in the presence of zinc chloride and phosphorous oxychloride at 130–140° for 1 h (25%).

Biological Activity

2,4-Dihydroxybenzophenone has potential effects on the stimulation of osteoblast differentiation and mitigate PDS-induced osteoporosisthrough the activation of the β-catenin pathway. Moreover, 2,4-Dihydroxybenzophenone demonstrated a capacity to enhance the expression of crucial osteogenic markers, including RUNX2, OSX, and ALP[2].

Toxicology

As a persistent and bioaccumulative compound, 2,4-Dihydroxybenzophenone (BP-1) exhibits estrogenic activity or anti-androgenic activity in vitro, which could pose potential risks to the ecological environment and human health. At present, there are a large amount of reports that concentrated on the biotoxicity of BP-1, mainly focusing on its endocrine disrupting effects and genetic toxicity. Endocrine-toxicological studies have shown that the toxicity of BP-1 is five times that of bisphenol A (BPA)[2].

Purification Methods

Recrystallise it from MeOH. [Beilstein 8 IV 2442.]

References

[1] Mengting Zou . “Effective degradation of 2,4-dihydroxybenzophenone by zero–valent iron powder (Fe0)-activated persulfate in aqueous solution: Kinetic study, product identification and theoretical calculations.” Science of the Total Environment 771 (2021): Article 144743.
[2] Mirissa Hewage Dumindu Kavinda and & Gi-Young Kim*. “2,4′-Dihydroxybenzophenone Exerts Bone Formation and Antiosteoporotic Activity by Stimulating the β-Catenin Signaling Pathway.” ACS Pharmacology and Translational Science 7 2 (2024): 395–405.

Material Safety Data Sheet(MSDS)

Questions And Answer

Spectrum Detail

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131-56-6

Chemical Properties

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Raw materials And Preparation Products

Raw materials

Preparation Products

Hazard Information

Chemical Properties

Uses

Uses

Description

Definition

Preparation

Biological Activity

Toxicology

Purification Methods

References

Material Safety Data Sheet(MSDS)

Questions And Answer

pollution

Spectrum Detail

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