Mps-BAY1 is an MPS1 inhibitor with anticancer activity. Mps-BAY1 inhibits cell proliferation and induces apoptosis by activating mitotic catastrophe in cancer cells, generating global aneuploidy and polyploidy. Mps-BAY1 can be used in the study of colorectal cancer and cervical cancer[1].
References
[1] Jemaa, et al. "Characterization of novel MPS1 inhibitors with preclinical anticancer activity." Cell Death & Differentiation 20.11 (2013): 1532-1545. DOI:10.1038/cdd.2013.105
