Description
Dactylocyclines is novel tetracycline derivatives produced by a Dactylosporangium sp. A screen for antibiotics with activity against tetracycline-resistant microorganisms has led to the isolation of Dactylosporangium sp. (ATCC 53693), a producer of several novel tetracycline derivatives. The major fermentation products, dactylocyclines A and B, were purified and MIC values determined against tetracycline-resistant and tetracycline-sensitive Gram-positive bacteria. The dactylocyclines represent the first naturally occurring tetracycline C2 amides which lack cross resistance with tetracycline.
Uses
Dactylocycline A is a tetracycline derivative with activity against some tetracycline-resistant microorganisms. Dactylocycline A is produced by fermentation of Dactylosporangium sp. and was found to be the most abundant glycoside in the initial fermentation. Dactylocycline A is acid-sensitive and readily hydrolyzes to the common sugar-free core substance dactylocyclinone. Although the sugar-free core has cross-resistance with tetracycline, Dactylocycline A exhibits activity against some tetracycline-resistant microorganisms[1].
References
[1] Dactylocyclines, novel tetracycline derivatives produced by a Dactylosporangium sp. II. Structure elucidation
