ChemicalBook CAS DataBase List 1245818-17-0

1245818-17-0

Name	Ppc-1
CAS	1245818-17-0
Molecular Formula	C21H25NO4
MDL Number	MFCD32664426
Molecular Weight	355.43
MOL File	1245818-17-0.mol

Chemical Properties

Boiling point	494.8±40.0 °C(Predicted)
density	1.105±0.06 g/cm3(Predicted)
pka	0?+-.0.50(Predicted)

Hazard Information

Description

Ppc-1 is an anti-obesity agent. It shows mitochondrial uncoupling activity in vitro and anti-obesity activity in vivo. Ppc-1 is also an inhibitor of interleukin-2 (IL2) production in Jurkat cells.

Uses

Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities[1][2][3][4].

in vivo

Ppc-1 (0-10 mg /kg; Intraperitoneal injection; once a week; for 8 weeks; female ICR mice) treatment suppresses weight gain with no abnormal effects on liver or kidney tissues, and no evidence of tumor formation^[1].
Serum fatty acid levels are significantly elevated in mice treated with Ppc-1, while body fat content remained low. After a single administration, Ppc-1 distributes into various tissues of individual animals at low levels. Ppc-1 stimulates adipocytes in culture to release fatty acids, which might explain the elevated serum fatty acids in Ppc-1-treated mice^[1].

Animal Model:	Female ICR mice^[1]
Dosage:	0 mg /kg , 0.16 mg /kg, 0.8 mg /kg, 4 mg /kg, and 10 mg /kg
Administration:	Intraperitoneal injection; once a week; for 8 weeks
Result:	Suppresseed weight gain in animals.

IC 50

IL-2

References

[1] Suzuki T, et al. Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold. PLoS One. 2015 Feb 10;10(2):e0117088. DOI:10.1371/journal.pone.0117088
[2] Ogura M, et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65. DOI:10.1016/j.bcp.2016.01.020
[3] Haruhisa Kikuchi a, et al. Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds. Tetrahedron 66 (2010) 6000-6007.
[4] Azelmat J, et al. Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondylium pseudo-candidum. Med Chem. 2015;11(7):666-9. DOI:10.2174/1573406411666150430121640

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