ChemicalBook CAS DataBase List 123-00-2

123-00-2

Name	N-(3-Aminopropyl)morpholine
CAS	123-00-2
EINECS(EC#)	204-590-2
Molecular Formula	C7H16N2O
MDL Number	MFCD00006184
Molecular Weight	144.21
MOL File	123-00-2.mol

Synonyms

3-(1-MORPHOLINO)-1-PROPYLAMINE 3-(4-MORPHOLINO)-1-PROPYLAMINE 3-MORPHOLIN-4-YLPROPAN-1-AMINE 3-MORPHOLIN-4-YL-PROPYLAMINE 3-MORPHOLINO-1-PROPYLAMINE 3-MORPHOLINOPROPYLAMINE 4-(3-AMINOPROPYL)MORPHOLINE 4-Aminopropyl morpholine 4-MORPHOLINEPROPANAMINE AKOS MSC-0738 AMP LABOTEST-BB LT00731422 N-(3-AMINOPROPYL)MORPHOLINE N-AMINOPROPYL-MORPHLINE N-AMINOPROPYLMORPHOLINE NAPM RARECHEM AL BW 1351 (3-Aminopropyl)morpholine 1-Amino-3-morpholinopropane 3-(4-Morpholinyl)-1-propanamine

Chemical Properties

Appearance	Clear liquid
Melting point	−15 °C(lit.)
Boiling point	224 °C(lit.)
density	0.987 g/mL at 25 °C(lit.)
vapor density	4.97
vapor pressure	11.5Pa at 20℃
refractive index	n20/D 1.4761(lit.)
Fp	210 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	1000g/l
form	Liquid
pka	10.30±0.10(Predicted)
color	Colorless to Almost colorless
PH	12 (H2O, 20℃)
Water Solubility	Soluble
Sensitive	Air Sensitive
Detection Methods	GC,NMR
BRN	105104
InChI	1S/C7H16N2O/c8-2-1-3-9-4-6-10-7-5-9/h1-8H2
InChIKey	UIKUBYKUYUSRSM-UHFFFAOYSA-N
SMILES	NCCCN1CCOCC1
LogP	-1.076 at 20℃ and pH10.81-11.03
Surface tension	70.3mN/m at 1g/L and 20℃
Dissociation constant	10.08
CAS DataBase Reference	123-00-2(CAS DataBase Reference)
NIST Chemistry Reference	4-Morpholinepropanamine(123-00-2)
EPA Substance Registry System	123-00-2(EPA Substance)

Safety Data

Symbol(GHS)	GHS05,GHS07
Signal word	Danger
Hazard statements	H302-H314
Precautionary statements	P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310
Hazard Codes	C,Xi
Risk Statements	R21:Harmful in contact with skin. R34:Causes burns. R21/22:Harmful in contact with skin and if swallowed . R36/37:Irritating to eyes and respiratory system . less more
Safety Statements	S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . less more
RIDADR	UN 2735 8/PG 2
WGK Germany	2
RTECS	QD7700000
F	10-34
TSCA	Yes
REACH Registrations	Active
HazardClass	8
PackingGroup	II
HS Code	29349990
Storage Class	8A - Combustible corrosive hazardous materials
Hazard Classifications	Acute Tox. 4 Oral Eye Dam. 1 Skin Corr. 1B
Safety Profile	A corrosive material. Moderately toxic by several routes. A severe skin and eye irritant. Combustible. Can react with oxidizing materials. To fight fire, use alcohol foam, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. less more
Toxicity	LD50 orl-rat: 3560 mg/kg UCDS** 3/25/70 less more

Hazard Information

General Description

A colorless liquid with a faint, fishlike odor. Burns, but requires some effort to ignite. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.

Reactivity Profile

N-AMINOPROPYLMORPHOLINE(123-00-2) behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Air & Water Reactions

Soluble in water.

Health Hazard

TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.

Chemical Properties

Clear liquid

Uses

3-(4-Morpholinyl)propylamine is catalytic agent, petrochemical additive. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

Uses

Fiber synthesis; chemical intermediate.

Definition

ChEBI: A member of the class of morpholines that is morpholine substituted by a 3-aminopropyl group a the N atom.

Hazard

Strongly irritant to tissue.

Synthesis

4542-47-6

110-91-8

123-00-2

The general procedure for the synthesis of morpholine and 3-(4-morpholinyl)-1-propanamine from 3-(4-morpholinyl)propanenitrile was as follows: sodium borohydride (0.6 g, 0.016 mol), 15 mL of tert-butanol, anhydrous nickel(II) chloride (1.0 g, 0.008 mol), and 3-(4-morpholinyl)propanenitrile (14 g, 0.1 mol) were added to the reaction system. The reaction was carried out at 70 °C for 8 hours. Upon completion of the reaction, morpholine (product 1) was obtained in 22 wt%. The results of mass spectral analysis were as follows: m/e (relative intensity, %): 88.8 (2) [M + 2], 87.9 (59) [M + 1], 86.8 (67) [M], 86.0 (100), 56.9 (86), 55.9 (98), 41.9 (28). Also, 3-N-morpholino-1-aminopropane (product 2) was obtained at 59 wt%. The results of mass spectrometry analysis were as follows: m/e (relative intensity, %): 145.0 (5) [M + 1], 128.0 (1.5), 126.8 (7), 113.0 (32), 101.0 (11), 100.0 (100), 86.0 (7), 72.0 (10), 70.0 (30), 57.0 (11), 56.0 (35 ), 42.0 (30).

References

[1] Russian Journal of General Chemistry, 2016, vol. 86, # 2, p. 273 - 280
[2] Zh. Obshch. Khim., 2016, vol. 86, # 2, p. 245 - 252,8

Material Safety Data Sheet(MSDS)

Spectrum Detail

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