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PQQ was first recognized as a bacterial cofactor. Under appropriate conditions, PQQ is capable of catalyzing continuous redox cycling (the ability to catalyze repeated oxidation and reduction reactions), as well as oxidative deaminations (Rucker et al., 2009), thus, it can serve as an antioxidant (Rucker et al. 2009). There is strong evidence PQQ may play an important role in pathways important to cell signaling. PQQ can also serve as an antioxidant. The importance of PQQ to mammalian health is evident when it is omitted from chemically defined diets. PQQ plays multiple physiological roles, such as promoting growth and reproduction, and providing neural and cardiovascular protection. It also enhances antioxidants, learning, memory, and immune function (Rucker et al., 2009). PQQ disodium salt is thought to have similar physiological and metabolic effects as PQQ.

Potential toxicants have not been identified in PQQ disodium salt. High-performance liquid chromatography (HPLC) reveals that JinCheng’s PQQ disodium salt is > 99.0% pure. Based on the purity profile, JinCheng considers the ingredient to meet or exceed food grade quality standards.

Pyrroloquinoline quinone disodium salt can act as an antioxidant and there is strong evidence that PQQ may play an important role in important pathways of cell signaling. PQQ plays a variety of physiological roles, such as promoting growth and reproduction and providing neurological and cardiovascular protection.

Pyrroloquinoline quinone disodium salt protects cells from oxidative damage and increases the mitochondrial membrane potential, which is essential for the production of ATP. It also stimulates enzyme activities, such as glutathione peroxidase and glutathione reductase, and prevents lipid peroxidation of human serum. This compound also inhibits radiation-induced cellular damage by preventing DNA strand breakage. It may be effective in treating diseases related to oxidative stress, such as diabetes and cancer.

1.Antioxidant. PQQ (pyrroloquinoline quinone) is an antioxidant and based on research, it shows to be more powerful at fighting free radicals than vitamin C. Antioxidants work better together, so it is unclear if taking PQQ alone as a supplement can help stop any diseases.
2.Mitochondrial dysfunction. Mitochondrial disease is a group of disorders caused by mitochondrial dysfunction. One study tested PQQ supplements in men who did aerobic exercise for 6 weeks. It increased mitochondria by affecting certain proteins during exercise. Another study showed that dietary PQQ raised mitochondria activity.
3.Anti-diabetes. Problems with mitochondria are part of what causes diabetes. Animal data shows that PQQ supplements fix mitochondrial problems from diabetes and make diabetic mice respond better to insulin. Yet, there isn’t any evidence that PQQ can help people with diabetes.
4.Inflammation. PQQ might lower inflammation by lowering the C-reactive protein, interleukin-6, and other markers in your blood.
5.Nootropic. Substances that help memory, attention, and learning are sometimes called nootropics. Studies show that PQQ raises blood flow to the cerebral cortex. This supplement also may also memory problems in older people. Sleep and mood. PQQ might help with better and longer sleep. By easing fatigue, it might also help to improve moods.

Methoxatin/pyrroloquinoline quinone (PQQ) is mostly seen in plants, few bacteria and single cell eukaryotes, like yeast. It is mainly obtained from methylotrophic bacteria. PQQ may also present in the tissues of mammals.

In bacteria, pyrroloquinoline quinone (PQQ) is used as a redox cycling cofactor. It acts as a cofactor (prosthetic group) for enzyme-catalyzed redox reactions of glucose and methanol dehydrogenase(s). PQQ is used in liposomes to establish a simple homogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic copolymers. In bovine plasma amine oxidase, methoxatin may acts as the cofactor.

From Self-Hacked: Anecdotally, some people have reported mild headaches and insomnia – usually either if too much is taken or if someone is very sensitive to the effects of supplements.
From Dr. Axe: The most commonly reported pyrroloquinoline quinone side effects include headaches, drowsiness and fatigue. Extremely high doses can also be dangerous and have actually been associated with some serious and potentially life-threatening effects on health.
keep.health/pqq-pyrroloquinoline-quinone/

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