Description
PQQ was first recognized as a bacterial cofactor. Under appropriate conditions, PQQ is capable
of catalyzing continuous redox cycling (the ability to catalyze repeated oxidation and reduction
reactions), as well as oxidative deaminations (Rucker et al., 2009), thus, it can serve as an
antioxidant (Rucker et al. 2009). There is strong evidence PQQ may play an important role in
pathways important to cell signaling. PQQ can also serve as an antioxidant. The importance of
PQQ to mammalian health is evident when it is omitted from chemically defined diets. PQQ
plays multiple physiological roles, such as promoting growth and reproduction, and providing
neural and cardiovascular protection. It also enhances antioxidants, learning, memory, and
immune function (Rucker et al., 2009). PQQ disodium salt is thought to have similar physiological and metabolic effects as PQQ.
Chemical Properties
Potential toxicants have not been identified in PQQ disodium salt. High-performance liquid
chromatography (HPLC) reveals that JinCheng’s PQQ disodium salt is > 99.0% pure. Based on
the purity profile, JinCheng considers the ingredient to meet or exceed food grade quality
standards.
Uses
Pyrroloquinoline quinone disodium salt can act as an antioxidant and there is strong evidence that PQQ may play an important role in important pathways of cell signaling. PQQ plays a variety of physiological roles, such as promoting growth and reproduction and providing neurological and cardiovascular protection.
Application
Pyrroloquinoline quinone disodium salt protects cells from oxidative damage and increases the mitochondrial membrane potential, which is essential for the production of ATP. It also stimulates enzyme activities, such as glutathione peroxidase and glutathione reductase, and prevents lipid peroxidation of human serum. This compound also inhibits radiation-induced cellular damage by preventing DNA strand breakage. It may be effective in treating diseases related to oxidative stress, such as diabetes and cancer.
General Description
Methoxatin/pyrroloquinoline quinone (PQQ) is mostly seen in plants, few bacteria and single cell eukaryotes, like yeast. It is mainly obtained from methylotrophic bacteria. PQQ may also present in the tissues of mammals.
Source
Methoxatin/pyrroloquinoline quinone (PQQ) is mostly seen in plants, few bacteria and single cell eukaryotes, like yeast. It is mainly obtained from methylotrophic bacteria. PQQ may also present in the tissues of mammals.
Biochem/physiol Actions
In bacteria, pyrroloquinoline quinone (PQQ) is used as a redox cycling cofactor. It acts as a cofactor (prosthetic group) for enzyme-catalyzed redox reactions of glucose and methanol dehydrogenase(s). PQQ is used in liposomes to establish a simple homogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic copolymers. In bovine plasma amine oxidase, methoxatin may acts as the cofactor.
Side effects
From Self-Hacked: Anecdotally, some people have reported mild headaches and insomnia – usually either if too much is taken or if someone is very sensitive to the effects of supplements.
From Dr. Axe: The most commonly reported pyrroloquinoline quinone side effects include headaches, drowsiness and fatigue. Extremely high doses can also be dangerous and have actually been associated with some serious and potentially life-threatening effects on health.
keep.health/pqq-pyrroloquinoline-quinone/
