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122-99-6

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Identification

Name
2-Phenoxyethanol
CAS
122-99-6
Synonyms
2-PHENOXYETHANOL
2-Phenoxyethyl alcohol
3-ETHYL-2-HEPTANOL
DOWANOL(TM) EPH
ETHYLENE GLYCOL MONOPHENYL ETHER
ETHYLENE GLYCOL PHENYL ETHER
MONOPHENYL GLYCOL
PHENOXETOL
PHENOXYETHANOL
PHENOXYETHANOLUM
PHENYL CELLOSOLVE
PHENYLGLYCOL
ROSE ETHER
1-Hydroxy-2-phenoxyethane
1-hydroxy-2-phenoxyethane[qr]
2-Fenoxyethanol
2-fenoxyethanol(czech)[qr]
2-Hydroxyethyl phenyl ether
2-Hydroxyethylphenylether
2-hydroxyethylphenylether[qr]
EINECS(EC#)
204-589-7
Molecular Formula
C8H10O2
MDL Number
MFCD00046644
Molecular Weight
138.16
MOL File
122-99-6.mol

Chemical Properties

Description
Phenoxyethanol is an organic chemical compound, a glycol ether often used in dermatological products such as skin creams and sunscreen. It is a colorless oily liquid. It is a bactericide (usually used in conjunction with quaternary ammonium compounds). Phenoxyethanol is used in many applications such as cosmetics, vaccines and pharmaceuticals as a preservative.
Appearance
clear colorless to light yellow viscous liquid
Melting point 
11-13 °C

mp 
11-13 °C

Boiling point 
247 °C(lit.)

bp 
247 °C(lit.)

density 
1.107 g/mL at 20 °C(lit.)

vapor density 
4.8 (vs air)

vapor pressure 
0.01 mm Hg ( 20 °C)

refractive index 
n20/D 1.539

FEMA 
4620 | 2-PHENOXYETHANOL
Fp 
>230 °F

storage temp. 
room temp
solubility 
soluble, clear, colorless to very faintly yellow
form 
Liquid
color 
Clear colorless
PH
7 (10g/l, H2O, 23℃)
explosive limit
1.4-9.0%(V)
Water Solubility 
30 g/L (20 ºC)
Merck 
14,7257
BRN 
1364011
Contact allergens
Phenoxyethanol is an aromatic ether-alcohol used mainly as a preservative, mostly with methyldibromoglutaronitrile (in Euxyl® K 400) or with parabens. Sensitization to this molecule is very rare.
Uses
phenoxyethanol is a broad-range preservative with fungicidal, bactericidal, insecticidal, and germicidal properties. It has a relatively low sensitizing factor in leave-on cosmetics. Phenoxyethanol can be used in concentrations of 0.5 to 2.0 percent, and in combination with other preservatives such as sorbic acid or parabens. In addition, it is used as a solvent for aftershaves, face and hair lotions, shampoos, and skin creams of all types. It can be obtained from phenol.
Uses
Phenoxyethanol is a preservative used in consumer and health care products, including vaccines, pen inks, ear drops, shampoos, skin cleansers, moisturizers, sun care products, and topical medicaments. The preservative Euxyl-K 400 also contains 2-phenoxyethanol, in combination with methyldibromoglutaronitrile.
Phenoxyethanol is commonly used in cosmetics for its antibacterial and antifungal properties. It is increasingly being used in vaccines as a substitute for thiomersal and is also a component of pen inks and, more rarely, ear drops.Reactions to phenoxyethanol have rarely been reported. Three cases of CoU induced by phenoxyethanol in cosmetics have been reported.2-Phenoxyethanol is used as a single agent and in combination with other preservatives such as 1,2-dibromo-2,4-dicyanobutane (Euxyl K 400) and parabens, or in conjunction with quaternary ammonium compounds.The possibility of immunological IgE-mediated reaction could not be confirmed because specific IgE against 2-phenoxyethanol was negative.
Uses
Antimicrobial preservative; also used topically in treatment of bacterial infections.
CAS DataBase Reference
122-99-6(CAS DataBase Reference)
NIST Chemistry Reference
2-Phenoxyethanol(122-99-6)
EPA Substance Registry System
122-99-6(EPA Substance)

Hazard Information

Chemical Properties
clear colorless liquid
General Description
Colorless liquid with a pleasant odor. Density 1.02 g/cm3. An irritant.
Reactivity Profile
ETHYLENE GLYCOL PHENYL ETHER(122-99-6) may react violently with strong oxidizing agents. May generate flammable and/or toxic gases with alkali metals, nitrides, and other strong reducing agents. May initiate the polymerization of isocyanates and epoxides.
Air & Water Reactions
Oxidizes in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Water soluble.
Health Hazard
May cause moderate eye irritation and moderate corneal injury. Excessive exposure may cause skin irritation and hemolysis.
Fire Hazard
This chemical is combustible.

Safety Data

Hazard Codes 
Xn,Xi
Risk Statements 
R22:Harmful if swallowed.
R36:Irritating to the eyes.
Safety Statements 
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
WGK Germany 
1

RTECS 
KM0350000

Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29094990
Safety Profile
Moderately toxic by ingestion and skin contact. A skin and severe eye irritant. Mutation data reported. Some glycol ethers have dangerous human reproductive effects. Combustible when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits acrid smoke and irritating fumes. To fight fEe, use CO2, dry chemical. Used as a solvent for ester-type resins. See also GLYCOL ETHERS.
Hazardous Substances Data
122-99-6(Hazardous Substances Data)

Raw materials And Preparation Products

Material Safety Data Sheet(MSDS)

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