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1-desoxymethylsphinganine is suitable for use for testing its cytotoxic effects on primary neuron-glia cultures. It is also suitable for use as a neurotoxic agent in human CD8+ T cells. In hereditary sensory and autonomic neuropathy type I, mutations in serine palmitoyltransferase long chain base subunit 1 resulting in altered substrate specificity and accumulation of 1.

ChEBI: A bioactive sphingoid which is the 1-deoxymethyl derivative of sphinganine.

1-desoxymethylsphinganine is neurotoxic towards CD8+ T cells and inhibits cytokine production. Howeverit is not cytotoxic to dopaminergic neurons.