GENERAL STEPS: To a solution of (R)-1-((S)-tert-butylsulfinyl)-2-(2,5-difluorophenyl)pyrrolidine (8.60 g, 29.9 mmol) in methanol (60 mL) was slowly added a dioxane solution (37.4 mL, 150 mmol) of 4M hydrochloric acid at 0 °C. The reaction mixture was stirred at room temperature for 12 hours. After completion of the reaction, the mixture was concentrated under vacuum and the residue was dissolved in water (100 mL) and washed with ethyl acetate (100 mL). The aqueous layer was separated and neutralized with 1N aqueous sodium hydroxide (150 mL) followed by extraction with dichloromethane (100 mL × 3). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford (R)-2-(2,5-difluorophenyl)pyrrolidine (5.06 g, 92% yield) as a slightly reddish oil.1H-NMR (CDCl3, Varian, 400 MHz): δ 1.56-1.65 (1H, m), 1.78-1.93 (3H m), 2.21-2.30 (1H, m), 3.01-3.08 (1H, m), 3.13-3.18 (1H, m), 4.39 (1H, t, J = 7.6 Hz), 6.82-6.88 (1H, m), 6.91-6.97 (1H, m), 7.22-7.26 (1H, m).
![Pyrrolidine, 2-(2,5-difluorophenyl)-1-[(S)-(1,1-dimethylethyl)sulfinyl]-, (2R)-](/CAS/20200515/GIF/1443538-31-5.gif)
